In “The Spectral Superman!”, a story in Action Comics #188 (November 1953), Superman heroically stops a nuclear reactor from exploding in Metropolis. As a result, he finds out his entire body is radioactive… maybe permanently!
Despite the super-melancholia that descends on Superman, he still manages to foil some criminals, even though his radioactivity continues to drive him into a super-funk.
Remember, this is the same guy who callously changed the entire timeline of the Earth just so he wouldn’t have to meet and put up with that pestering love-of-his-life Lois.
Luckily a well-timed lightning bolt manages to cure Superman of radioactivity before his life gets even more awkward by a suspicious Lois Lane.
P.S. Jimmy Olsen continues to make regular-but-minor appearances in the comic books to match the Adventures of Superman TV series, though his physical appearance is not very consistent. In this issue he seems to have blonde hair.